COMPOSITIONS DE NANOPARTICULES POUR L'ADMINISTRATION CIBLEE DE MEDICAMENTS LIPOPHILES ET DE PROMEDICAMENTS LIPOPHILES LABILES EN MILIEU ACIDE D'AGENTS CHIMIOTHERAPEUTIQUES ANTI-CANCEREUX, ET LEUR PREPARATION
MCCHESNEY, JAMES D.,NIKOULIN, IGOR,BANNISTER, STEVE J.,RODENBURG, DOUGLAS L.
申请号：
CA2922002
公开号：
CA2922002A1
申请日:
2014.09.13
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol； optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.
