INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YEUNGNAM UNIVERSITY
发明人:
CHO, KYUNG-HYUN
申请号：
KR2011007966
公开号：
WO2012057492A3
申请日:
2011.10.25
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a rapamycin formulation using recombinant high-density lipoprotein which includes a mutant of apolipoprotein. More particularly, the present invention relates to a rapamycin formulation which improves the solubility of rapamycin and also enhances various medical effects, such as anti-aging and anti-arteriosclerosis, using recombinant high-density lipoprotein, which includes the V156K apolipoprotein mutant.La présente invention concerne une formulation de rapamycine utilisant une lipoprotéine haute densité recombinante qui comprend un mutant dapolipoprotéine. Plus particulièrement, la présente invention concerne une formulation de rapamycine qui améliore la solubilité de la rapamycine et augmente également différents effets médicaux, tels que des effets antivieillissement et anti-artériosclérose, utilisant une lipoprotéine haute densité recombinante, qui comprend le mutant dapolipoprotéine V156K.본 발명은 아포지단백질 변이체를 포함한 재조합 고밀도지단백질을 이용한 라파마이신 제형에 관한 것으로, 보다 상세하게는 아포지단백질 변이체 V156K를 포함한 재조합 고밀도지단백질을 이용하여 라파마이신의 용해도를 개선시키고 노화 억제 및 동맥경화 억제와 같은 의학적 용도를 향상시킨 라파마이신 제형에 관한 것이다.
