Ultradrobne nanocząstki z funkcjonalizowaną matrycą poliorganosiloksanową i zawierające kompleksy metali； sposoby ich wytwarzania i ich zastosowania w obrazowaniu medycznym
Université Lyon 1 Claude Bernard;Institut National des Sciences Appliquées de Lyon;Nano H
发明人:
LUX, FRANÇOIS,TILLEMENT, OLIVIER,SAINT JEAN, MAXIME,MOWAT, PIERRE,PERRIAT, PASCAL,ROUX, STÉPHANE,MIGNOT, ANNA
申请号：
PL11716589
公开号：
PL2563408T3
申请日:
2011.05.02
申请国别(地区):
PL
年份:
2019
代理人:
摘要：
The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations； a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an -Si-C- covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations； and optionally another functionalizing graft Gf* bound to the POS matrix by an -Si-C- covalent bond (where Gf* can be derived from a hydrophilic compound (PEG)； from a compound having an active ingredient PA1； from a targeting compound； from a luminescent compound (fluorescein). The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
