ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES； METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY
NANOH;UNIVERSITE LYON 1 CLAUDE BERNARD;INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
发明人:
François LUX,Olivier TILLEMENT,Maxime SAINT JEAN,Pierre MOWAT,Pascal PERRIAT,Stéphane ROUX,Anna MIGNOT
申请号：
US15677167
公开号：
US20180008729A1
申请日:
2017.08.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
