ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES； METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY
The invention relates to novel biocompatible hybrid nanoparticles of very small size that are of use in particular for diagnosis and/or therapy. The objective of the invention is to provide novel nanoparticles which are of use in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which are more effective than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high metal (e.g. rare earth) loading rate, in particular so as to have, in imaging (e.g. MRI), a strong enhancement and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, of diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations, optionally associated with doping cations； a DTPABA (diethylenetriaminepentaacetic acid bisanhydride) chelating C1 graft bonded to the POS matrix via -Si-C- covalent bonding, and present in sufficient amount to be able to complex all the gadolinium cations； and optionally an other functionalization graft Gf* bonded to the POS matrix via -Si-C- covalent bonding (it being possible for Gf* to result from a hydrophilic compound (PEG)； from a compound comprising an active ingredient PA1； from a targeting compound； from a luminescent compound (fluorescein)). The method for obtaining these nanoparticles and the uses thereof in imaging and in therapy are also part of the invention.Buluş, özellikle teşhis ve/veya terapi için kullanışlı olan, çok düşük boya sahip, biyouyumlu, hibrit yeni nanopartiküller ile ilgilidir. Buluşun amacı özellikle görüntülemede (örneğin MRI) ve/veya diğer teşhis tekniklerinde kontrast maddeleri olarak ve/veya terapi maddeleri olarak kullanışlı olan, bilinen türdeki aynı nanopartiküllerden daha performanslı olan ve özellikle görüntülemede (örneğin MRI) yüksek zenginleştirmeye ve yüksek frekanslara karşı doğru bir yanıta (ar
