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Mannose derivatives for the treatment of bacterial infections
专利权人:
VERTEX PHARMACEUTICALS INCORPORATED
发明人:
YOUSSEF BENNANI,CAROLINE CADILHAC,SANJOY KUMAR DAS,EVELYNE DIETRICH,MICHAEL GALLANT,BINGCAN LIU,OSWY PEREIRA,YEEMAN RAMTOHUL,T. JAGADEESWAR REDDY,LOUIS VAILLANCOURT,FREDERIC VALLEE,CONSTANTIN YANNOPOU
申请号:
ARP130100754
公开号:
AR092307A1
申请日:
2013.03.07
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
It also provides pharmaceutically acceptable ingredients containing compounds and methods of use of ingredients for the treatment of bacterial infections and processes. 1. Claim 1: a formula compound (1),Or a salt acceptable for a medicament containing x-or831111;And it is absent or is an aliphatic C₁₋₁₀ where up to four methylene units of the aliphatic C₁₋₁₀ can optionally be replaced by -NR⁸,- that is...- yes.-C (O) --S (O) -O-SO8322-;And it is optionally substituted by 1-2 cases of halogen, OH, C₃₋₆ cycloalkyl or C₁₋₆ aliphatic;R¹ is aryl C₆₋₁₀ optionally substituted by one or more R³A groups; and R² is H, C₃₋₆ cycloalkyl,3-8 membered heterocyclyl, C₆₋₁₀ aryl,(Aril C) - (alquilo C) -O heteromorphism consisting of 5-10 members; each R2 km is replaced by one or more R3 B groups independently and optionally by one R3 group;Each R3a and R3b is an independent halogen.C₃₋₆ cycloalkyl,3-8 membered heterocyclyl, (C ar aryl) - (C₁₋₆ alkyl) -,or an aliphatic C₁₋₁₀ where up to four methylene units of the aliphatic C₁₋₁₀ can optionally be replaced by -NR⁴,- that is...- yes.-C (O) --S (O) --SO₂-,That's it, that's it.each R³A and R³B is independently and optionally substituted by one or more R⁴ or R⁴A groups; R³ is C₃₋₆ cycloalkyl,3-8 membered heterocyclyl, C₆₋₁₀ aryl,(Cil aryl) - (C₁₋₆ alkyl) or 5-10 membered heteroaryl; each R³ is optionally substituted by one or more R⁴ or R⁴A groups; R⁴ is H, C₁₋₆ alkyl,C₁₋₆ alkenyl,C₁₋₆ alkynyl,C₃₋₈ cycloalkyl,3-8 membered heterocyclyl, C₆₋₁₀ aryl or 5-10 membered heteroaryl; each R⁴ is optionally substituted by one or more R⁴B groups; R⁴A is halogen, CN, NO₂,or an aliphatic C₁₋₁₀ where up to four methylene units of the aliphatic C₁₋₁₀ can optionally be replaced by -NR⁴,- that is...- yes.- C (O) --S (O) --SO₂-,That's it, that's it.Each r83088a can be replaced by 1-3 halogen; r83088b is halogen, CN, no.8322;or an aliphatic C₁₋₁₀ where up to four methylene units of the aliphatic C₁₋₁₀ can optionally be replaced by -NR, -O-,- yes.-C (O) -S (
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