CONSTRUCTION OF AN OBLIGATORY VECTOR BASED ON ONCOLITIC SIMPLE HERPES VIRUSES (oHSV) AND CONSTRUCTION FOR CANCER THERAPY

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专利权人:

发明人:

申请号：

RU2018136481

公开号：

RU2018136481A3

申请日:

申请国别(地区):

RU

年份:

2020

代理人:

摘要：

An obligate oHSV vector comprising modified viral DNA genome is provided. A recombinant oHSV-1 construct comprising the obligate oHSV vector and a heterologous nucleic acid sequence encoding an immunostimulatory and/or immunotherapeutic agent is also provided. Compositions comprising the recombinant oHSV-1 construct can be used for treating cancers.

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