OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTJU "IVA FARM
发明人:
Mark Borisovich BALAZOVSKIJ,Viktor Georgievich ANTONOV,Oleg Aleksandrovich IGNATENKO
申请号：
US16603042
公开号：
US20200121802A1
申请日:
2018.07.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Pharmaceutical composition comprising glutathione disulphide or pharmaceutically acceptable organic or inorganic salt thereof and glutathione disulfide S-oxide of the following structure:or pharmaceutically acceptable organic or inorganic salt thereof for eliminating dose-related toxicity and enhancing the therapeutic activity of a pharmacologically active compound in the treatment of infectious and non-infectious diseases is provided. Typically, the composition comprises glutathione disulfide S-oxide in an amount of 0.01-10% by weight of the total composition, and additionally a metal (Me) in the form of coordination compound(s) containing Me-S-glutathione bond, said metal is selected from the platinum group, typically it is platinum. The amount of d-metal coordination compound administered to a patient can be 10−；3 to 10−；15 mol/kg of body weight. The composition can be used in combination with pharmacologically active compound, which is an anticoagulant, factor Xa inhibitor, antimicrobial or antiviral agents to increase their therapeutic activity and eliminate dose-related toxicity.
