The present invention is related to compounds of Formula (I), namely novel urea carbonyl disulfide derivatives said compounds for use as a medicament a pharmaceutical composition comprising said compounds said compounds for use in the treatment of certain diseases or conditions the use of said compounds as a reactive in an in vitro biological assay requiring inhibition of GSK-3 the use of said compounds in the preparation of a medicament for the treatment of certain diseases or conditions and a method of treating a disease, comprising administering said compounds.