PROBLEM TO BE SOLVED: To provide a cell differentiation promoter that has no side effects and is excellent in safety and to provide a cosmetic that contains the cell differentiation promoter and can maintain normal skin functions and can improve a skin barrier function to form a healthy skin.SOLUTION: The invention relates to a cell differentiation promoter containing as an active ingredient a fermentation product obtained by fermenting one or more kinds of flower portions selected from plants belonging to Asteraceae Inula genus Inula japonica Thunb., Matricaria tetragonosperma genus Matricaria chamomilla L., and Chrysanthemum genus Chrysanthemum indicum var. indicum. with lactic acid bacteria and/or yeast fungus.COPYRIGHT: (C)2015,JPO&INPIT【課題】副作用がなく安全性に優れた細胞分化促進剤、および該細胞分化促進剤を配合した、表皮の正常な皮膚機能を維持し表皮バリア機能を向上させ健全な表皮を形成しうる化粧料の提供。【解決手段】キク科植物のオグルマ属(Inula)旋覆花、シカギク属(Matricaria)カミツレ、キク属(Chrysanthemum)野菊に属する植物から選択される1種又は2種以上の花部を、乳酸菌及び/又は酵母菌により発酵させて得られた発酵物を有効成分とする細胞分化促進剤。【選択図】図-1