An orthopedic device includes a patient-specific acetabular guide that can be used for preparing an acetabulum of a patient to receive an acetabular implant. The acetabular guide has a dome-shaped body with a peripheral annular rim and an outer three-dimensional surface configured to match an acetabulum of a specific patients hip joint from three-dimensional medical images of the patients hip joint. A patient-specific registration guide is removably attached to the peripheral rim and has a longitudinal bore defining a patient-specific alignment axis with an alignment orientation configured for guiding an acetabular implant for the patient. The registration guide has a patient-specific undersurface configured to mate with a corresponding surface of periacetabular surface of the acetabulum of the patient.
