Eric E. Swayze,Andrew M. Siwkowski,Punit P. Seth,Thazha P. Prakash
申请号：
US14628044
公开号：
US09428750B2
申请日:
2015.02.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
