Balkrishen Bhat;Thazha P. Prakash;Andrew M. Siwkowski;Eric E. Swayze
发明人:
Thazha P. Prakash,Andrew M. Siwkowski,Eric E. Swayze,Balkrishen Bhat
申请号：
US13125560
公开号：
US20120059045A1
申请日:
2009.10.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present disclosure provides oligomeric compounds comprising at least one 2′-fluoroethoxy modified nucleoside of formula I and methods of using these oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
