IL-15 heterogeneous dimer protein and uses thereof

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专利权人:

Ltd.;Shanghai Hengrui Pharmaceutical Co.;Shanghai Hengrui Pharmaceutical Co., Ltd.;Jiangsu Hengrui Medicine Co., Ltd.

发明人:

Qu, Xiangdong,Ye, Xin,Yuan, Jijun,Zhang, Lei,Chen, Kan,Zhang, Lianshan,Cao, Guoqing,Xu, Zhibin,Tao, Weikang

申请号：

AU2014377106

公开号：

AU2014377106A1

申请日:

2014.12.25

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Disclosed are an IL-15 heterogeneous dimer protein and uses thereof. The IL-15 heterogeneous dimer protein comprises protein (I) and protein (II). The protein (I) is formed by means of reconstruction between IL-15 or a modification thereof and a first Fc modification； the protein (II) a second Fc modification, or is formed by means of reconstruction between IL-15Rα or a modification thereof and the second Fc modification； and the first Fc modification and the second Fc modification are connected in a manner of Knob-into-Hole. The IL-15 heterogeneous dimer protein has obvious tumor suppression activity, and has better bioactivity and an extended in-vivo half-life period compared with a single IL-15 molecule.

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中国工程科技知识中心

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