Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.所提供的是以5員雜環為主之p38激酶抑制劑。進一步提供的是以吡唑和咪唑為主之p38激酶抑制劑，包括p38α和p38β激酶的抑制劑。亦提供含該化合物的醫藥組成物。亦提供使用該化合物和組成物的方法，包括治療、預防或改善一或多種由p38激酶所媒介疾病與失調(包括但不限於發炎疾病和失調)之症狀的方法。
