The compound of present invention offer formula 1 and its synthesis and application method. Preferred compound is effective inhibitor of c-Met protein kinases, and can treat abnormal cell growth obstacle, such as cancer with what.本發明提供式1的化合物及其合成與使用方法。優選化合物爲c-Met蛋白激酶的有效抑制劑,並且可用於治療異常細胞生長障礙,例如癌症。