A collagen-coated tissue-based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. The tissue-based membrane is a serous membrane having a fibrous surface and a smooth surface and the collagen is coated on the fibrous surface. Also provided are methods for making the collagen-coated tissue-based membrane.Cette invention concerne une membrane à base de tissu enduite de collagène dont les deux côtés lisses inhibent l'adhésion cellulaire et tissulaire. L'invention concerne également des méthodes permettant de fabriquer ce type de membrane.