A tissue-based coated membrane, comprises a serous membrane and a collagen coating. The serous membrane has a fibrous surface and a smooth surface and the collagen coating, having a thickness of 5 µm to 100 µm, is present on the fibrous surface. The collagen-coated fibrous surface is smooth, and both the collagen-coated fibrous surface and the smooth surface adhere poorly to cells and tissues. Further disclosed is a method for preparing a biocompatible collagen-coated serous membrane, the method comprising: - scraping a fibrous side of a serous membrane to remove adhering fibres； - treating the serous membrane to remove cells, lipids, and extractable blood and non-collagenous molecules； - freeze-drying the treated serous membrane； - compressing the fibrous side of the serous membrane； - coating the fibrous side of the serous membrane with a collagen； and - exposing the collagen coated serous membrane to a crosslinking agent to effect crosslinking.
