Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith

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专利权人:

SIGNAL PHARM LLC; LLC;Signal Pharmaceuticals

发明人:

CALABRESE, Andrew Antony,JEFFY, Brandon David,ROBINSON, Dale,ZHU, Dan,HUANG, Dehua,ELSNER, Jan,BOYLAN, John Frederick,TEHRANI, Lida,NAGY, Mark,RAHEJA, Raj,ERDMAN, Paul,NARLA, Rama,HARRIS, Roy,TRAN, Ta,CALABRESE ANDREW ANTONY,JEFFY BRANDON DAVID,ROBINSON DALE,ZHU DAN,HUANG DEHUA,ELSNER JAN,BOYLAN JOHN FREDERICK,TEHRANI LIDA,NAGY MARK,RAHEJA RAJ,ERDMAN PAUL,NARLA RAMA,HARRIS ROY,TRAN TAM,RIGGS JENNIF

申请号：

ES14702393

公开号：

ES2638179T3

申请日:

2014.01.15

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound of formula (I): ** Formula ** and pharmaceutically acceptable salts, tautomers, stereoisomers, enantiomers and isotopologists thereof, wherein: R1 is substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C3-8 cycloalkyl , or substituted or unsubstituted non-aromatic heterocyclyl； R2 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl； R3 is substituted or unsubstituted heterocyclyl or substituted or unsubstituted aryl, and L is O； provided that the compound is not 4 - [[trans-3- (methylamino) cyclobutyl] oxy] -N- (1-methyl-1 H -pyrazol-4-yl) -5- (pyridin-3-yl) - 7H-pyrrolo [2,3-d] pyrimidin-2-amine, N- [trans-3 - [[2 - [(1-methyl-1H-pyrazol-4-yl) amino] -5- (2-pyridinyl ) -7H-pyrrolo [2,3-d] pyrimidin-4-yl] oxy] cyclobutyl] -2-Propenamide, N-methyl-N- [trans-3 - [[2 - [(1-methyl-1H- pyrazol-4-yl) amino] -5- (3-pyridinyl) -7H-pyrrolo [2,3-d] pyrimidin-4-yl] oxy] cyclobutyl] -2- Propenamide, N- [trans-3- [ [2 - [(1,3-dimethyl-1H-pyrazol-4-yl) amino] -5- (2-pyridinyl) -7H-pyrrolo [2,3-d] pyrimidin-4-yl] oxy] cyclobutyl] -N-methyl-2- Propenamide, N-methyl-N- [trans-3 - [[5- (1-methyl-1H-pyrazol-3-yl) -2 - [(1-methyl-1H-pyrazole- 4-yl) amino] -7H-pyrrolo [2,3-d] pyrimidin-4- yl] oxy] cyclobutyl] -2-Propenamide, N-methyl-N- [trans-3 - [[2 - [(1 -methyl-1H-pyrazol-4-yl) amino] -5- (2-pyridinyl) -7H-pyrrolo [2,3-d] pyrimidin-4-yl] oxy] cyclobutyl] -2- Propenamide, N-methyl -N- [trans-3 - [[5- (1-methyl-1H-pyrazol-4-yl) -2 - [(1-methyl-1H-pyrazol-4-yl) amino] -7H-pyrrolo [2 , 3-d] pyrimidin-4- yl] oxy] cyclobutyl] -2-Propenamide, N- [c is-3 - [[2 - [(1-methyl-1H-pyrazol-4-yl) amino] -5- (3-pyridinyl) -7H-pyrrolo [2,3-d] pyrimidin-4-yl] oxy ] cyclobutyl] -2-Propenamide or 1 - [(3R, 4R) -3-methoxy-4 - [[[2 - [(1-methyl-1H-pyrazol-4-yl) amino] -5- (2- pyridinyl) -7H-pyrrolo [2,3-d] pyrimidin-4-yl] oxy] methyl] -1-pyrrolidinyl] -2-Propen-1-one.Un compuesto de fórmula (I):**Fórmula** y sales, tautómeros, estereoisómeros, ena

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