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Luteinizing-hormone ligand and ligand-gonadotrophin complex
专利权人:
Institut National de la Recherche Agronomique
发明人:
Aubrey, Nicolas,Maurel, Marie-Christine,Reiter, Eric,Guillou, Florian
申请号:
AU2011330743
公开号:
AU2011330743A1
申请日:
2011.11.21
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The invention relates to a ligand of a luteinizing hormone (LH), characterized in that it comprises the paratope of an ovine anti-LH antibody of which the variable domain of the heavy chain contains the following CDRs: - VH-CDR1, defined by the sequence GYTFTNYW (SEQ ID NO: 13) - VH-CDR2, defined by the sequence IYPGGGYT (SEQ ID NO: 14) - VH-CDR3, defined by the sequence ARTPLYGSSYGGFAY (SEQ ID NO: 15) and the variable domain of the light chain contains the following CDRs: - VL-CDR1, defined by the sequence QGISNY (SEQ ID NO: 16) - VL-CDR2, defined by the sequence YTS - VL-CDR3, defined by the sequence QQYSKLPWT (SEQ ID NO: 17). The invention also relates to a ligand-gonadotrophin (LH, hCG, FSH) complex. The ligand or the complex according to the invention can be used to induce ovulation in a female mammal.
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中国工程科技知识中心
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