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LUTEINIZING-HORMONE LIGAND AND LIGAND-GONADOTROPHIN COMPLEX
专利权人:
Florian Guillou;Nicolas Aubrey;Marie-Christine Maurel;Eric Reiter
发明人:
Marie-Christine Maurel,Eric Reiter,Florian Guillou,Nicolas Aubrey
申请号:
US13988203
公开号:
US20130315928A1
申请日:
2011.11.21
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to a ligand of a luteinizing hormone (LH), characterized in that it comprises the paratope of an ovine anti-LH antibody of which the variable domain of the heavy chain contains the following CDRs: —VH-CDR1, defined by the sequence GYTFTNYW (SEQ ID NO: 13); —VH-CDR2, defined by the sequence IYPGGGYT (SEQ ID NO: 14); —VH-CDR3, defined by the sequence ARTPLYGSSYGGFAY (SEQ ID NO: 15); and the variable domain of the light chain contains the following CDRs: —VL-CDR1, defined by the sequence QGISNY (SEQ ID NO: 16); —VL-CDR2, defined by the sequence YTS; —VL-CDR3, defined by the sequence QQYSKLPWT (SEQ ID NO: 17). The invention also relates to a ligand-gonadotrophin (LH, hCG, FSH) complex. The ligand or the complex according to the invention can be used to induce ovulation in a female mammal.
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中国工程科技知识中心
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