ERIC REITER,FLORIAN GUILLOU,MARIE-CHRISTINE MAUREL,NICOLAS AUBREY
申请号：
BR112013012297
公开号：
BR112013012297A2
申请日:
2011.11.21
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The invention relates to a ligand of a luteinizing hormone (LH), characterized in that it comprises the paratope of an ovine anti-LH antibody of which the variable domain of the heavy chain contains the following CDRs: -VH-CDR1, defined by the sequence GYTFTNYW (SEQ ID NO: 13)； -VH-CDR2, defined by the sequence IYPGGGYT (SEQ ID NO: 14)； -VH-CDR3, defined by the sequence ARTPLYGSSYGGFAY (SEQ ID NO: 15)； and the variable domain of the light chain contains the following CDRs: -VL-CDR1, defined by the sequence QGISNY (SEQ ID NO: 16)； -VL-CDR2, defined by the sequence YTS； -VL-CDR3, defined by the sequence QQYSKLPWT (SEQ ID NO: 17). The invention also relates to a ligand-gonadotrophin (LH, hCG, FSH) complex. The ligand or the complex according to the invention can be used to induce ovulation in a female mammal.
