Has a GPR119 receptor agonist activity, useful as a medicament, the present invention relates acceptable salts thereof pharmacologically novel pyrrolo the following formula [I] or [2,3-d] pyrimidine compounds. Wherein, E is the formula: group represented by -NH-, halogen atom, ring A is formula (aromatic ring and 6-membered aromatic ring may contain 1 to 2 nitrogen atoms as heteroatoms : Well, hydrogen, alkyl, R b and R a is hydroxyalkyl, etc. are the same or different), R 1 is an acyl group, R 2 is a halogen atom may be substituted with a group represented by -CONR a R b Or am I a cyano group. ]本発明は、GPR119受容体アゴニスト作用を有し、医薬として有用な、下記式[I]の新規ピロロ[2,3-d]ピリミジン化合物又はその薬理的に許容し得る塩に関する。〔式中、Eは式:-NH-で示される基等、環Aはヘテロ原子として1~2個の窒素原子を含有していてもよい6員芳香環(該芳香環はハロゲン原子、式:-CONRaRbで示される基等で置換されていてもよく、Ra及びRbは同一又は異なって水素、アルキル、ヒドロキシアルキル等)、R1はアシル基等、R2はハロゲン原子又はシアノ基を表す。〕
