The embodiments herein discloses a device with simultaneous X-ray and infrared acquisition and processing systems for an enhance breast imaging. The device has a positioning assembly housed inside a closed chamber and provided with the Infrared and X-ray imaging systems to simultaneously capture an infra red image and an X-ray image of the breast under examination. A patient support table with an opening is provided to enable a patient to lie in a prone position without compressing a breast during imaging. The device is used to correlate anatomical and physiological characteristics and post process analysis of a breast tissue thereby reducing a number of to false positive results. Further the device helps in focusing on a suspected area in a follow-up procedure and aids post processing treatment like targeted biopsy and targeted radiation.