Disclosed is a device with a simultaneous X ray and infrared acquisition and processing system for enhanced breast imaging. The device has a positioning assembly (3) housed inside a closed chamber (4) and provided with infrared and X ray imaging systems to simultaneously capture an infrared image and an X ray image of the breast (14) under examination. A patient support table (2) with an opening is provided to enable a patient to lie in a prone position without compressing a breast (14) during imaging. The device is used to correlate anatomical and physiological characteristics and post process analysis of a breast tissue thereby reducing a number of false positive results. Further the device helps in focusing on a suspected area in a follow up procedure and aids post processing treatment like targeted biopsy and targeted radiation.