<;P>;PROBLEM TO BE SOLVED: To obtain a functional material which has activities/effects such as anti-oxidation, liver function improvement and angiotensin conversion enzyme inhibition and is highly safe. <;P>;SOLUTION: The manufacturing process of the functional material comprises re-fermenting liquified sake lees. The manufacturing process may involve a protease treatment. <;P>;COPYRIGHT: (C)2006,JPO&NCIPI