COLVIN, ARTHUR E., JR.,柯文 亚瑟Ｅ 二世,柯文 亞瑟Ｅ 二世,JIANG, HUI,姜辉,姜輝,柯文 亚瑟E 二世,柯文 亞瑟E 二世
申请号：
TW102133395
公开号：
TW201418419A
申请日:
2013.09.14
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.本發明提供一種具有活體內功能之可植入裝置，其中該裝置之該功能受通常與因組織損傷所致之發炎反應以及慢性異物反應相關之ROS負面地影響，該裝置至少部分地由防止因任何發炎反應而損壞該裝置的保護材料、結構及/或塗層圍繞。保護材料、結構及/或塗層為生物相容性金屬，較佳為銀、鉑、鈀、金、錳或其合金或氧化物，其分解反應性氧物質(reactive oxygen species，ROS)(諸如過氧化氫)且防止ROS在該裝置之表面上或在該裝置內氧化分子。保護材料、結構及/或塗層藉此防止ROS使該可植入裝置之該活體內功能劣化。
