abstract provided herein are methods of preparing macrolides by coupling of eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. intermediates in the synthesis of macrolides including the eastern and western halves are also provided. pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. a general diastereoselective aldol methodology used in the synthesis of the western half is further provided. Methods of preparing macrolides by coupling an eastern and western half, followed by macrocyclization, to provide macrolides, including also known and novel macrolides are provided herein. Intermediates in macrolide synthesis including the eastern and western halves are similarly provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are likewise provided. A general diastereoselective aldol methodology used in western half synthase is also provided. 1/1abstract provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. intermediates in the synthesis of macrolides including the eastern and western halves are also provided. pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. a general diastereoselective aldol methodology used in the synthesis of the western half is further provided. tradução do resumo resumo patente de invenção para "macrolídeos e métodos de sua preparação e uso" são fornecidos aqui métodos de preparer macrolídeos pelo acoplamento de uma metade oriental e ocidental, seguido por macrociclização, para fornecer macrolídeos, incluindo igualmente macrolídeos conhecidos e novos. intermediár
