The present invention relates to a composition comprising lactuca indica var. laciniata as an active ingredient for immunity enhancement and, more specifically, to a technical feature capable of enhancing immunity by facilitating generation of nitric oxide (NO), anti-allergic activity, and antioxidant activity. Accordingly, the composition of the present invention can be provided as pharmaceutical compositions, functional health foods, cosmetics, or animal feeds which can be used for various diseases caused by lack of immune or abnormal conditions.
