COMPOSITIONS ET PROCÉDÉS D'INACTIVATION DE L'EXPRESSION DE L'APOLIPOPROTÉINE C-III

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专利权人:

PROTIVA BIOTHERAPEUTICS INC.

发明人:

MACDONALD, MARCIA,LEE, AMY C.H.,MACLACHLAN, IAN

申请号：

EP10733190

公开号：

EP2405921A4

申请日:

2010.01.26

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia).

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