COMPOSITIONS ET PROCEDES D'INACTIVATION DE L'EXPRESSION DE L'APOLIPOPROTEINE C-III

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专利权人:

PROTIVA BIOTHERAPEUTICS; INC.

发明人:

MACDONALD, MARCIA,LEE, AMY C. H.,MACLACHLAN, IAN

申请号：

CA2750561

公开号：

CA2750561C

申请日:

2010.01.26

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention provides compositions comprising therapeutic nucleicacids such as interfering RNA thattarget apolipoprotein C-III (APOC3) gene expression, lipid particlescomprising one or more (e.g., a cocktail) of the therapeuticnucleic acids, methods of making the lipid particles, and methods ofdelivering and/or administering the lipid particles (e.g., forthe treatment of lipid diseases or disorders such as atherosclerosis or adyslipidemia such as hypertriglyceridemia orhypercholesterolemia).

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