OTTO, Christiane,WOLF, Siegmund,FREIBERG, Christoph,HARRENGA, Axel,GREVEN, Simone,TRAUTWEIN, Mark,BRUDER, Sandra,EICKER, Andrea,WILMEN, Andreas
申请号：
ES10776753
公开号：
ES2603352T3
申请日:
2010.11.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Antibody 005-C04 or defined mature variants thereof, according to table 5 or antigen binding fragments thereof, which antagonize prolactin receptor mediated signaling (PRLR) and which bind epitopes of the receptor extracellular domain of prolactin and human polymorphic variants thereof, so that the amino acid sequence of the prolactin receptor extracellular domain corresponds to SEQ ID NO: 70 and the nucleic acid sequence corresponds to SEQ ID NO: 71, so that SEQ ID NO: 6 of the variable heavy chain of antibody 005-C04 corresponds to HCDR1, Seq ID NO: 12 corresponds to HCDR2 and SEQ ID No. 17 corresponds to HCDR3 and SEQ ID No. 23 of the variable light chain corresponds to LCDR1, Seq ID NO: 28 corresponds to LCDR2 and SEQ ID No. 33 corresponds to LCDR3, and so that a. SEQ ID NO: 103 of the variable heavy chain corresponds to HCDR1, Seq ID NO: 104 corresponds to HCDR2 and SEQ ID No. 17 corresponds to HCDR3 and SEQ ID No. 136 of the variable light chain corresponds to LCDR1, Seq ID NO: 140 corresponds to LCDR2 and SEQ ID No. 33 corresponds to LCDR3； or b. SEQ ID NO: 103 of the variable heavy chain corresponds to HCDR1, Seq ID NO: 105 corresponds to HCDR2 and SEQ ID No. 17 corresponds to HCDR3 and SEQ ID No. 136 of the variable light chain corresponds to LCDR1, Seq ID NO: 139 corresponds to LCDR2 and SEQ ID No. 33 corresponds to LCDR3； or c. SEQ ID NO: 6 of the variable heavy chain corresponds to HCDR1, Seq ID NO: 12 corresponds to HCDR2 and SEQ ID No. 17 corresponds to HCDR3 and SEQ ID No. 23 of the variable light chain corresponds to LCDR1, Seq ID NO: 139 corresponds to LCDR2 and SEQ ID No. 33 corresponds to LCDR3； or d. SEQ ID NO: 6 of the variable heavy chain corresponds to HCDR1, Seq ID NO: 12 corresponds to HCDR2 and SEQ ID No. 17 corresponds to HCDR3 and SEQ ID No. 23 of the variable light chain corresponds to LCDR1, Seq ID NO: 141 corresponds to LCDR2 and SEQ ID No. 33 corresponds to LCDR3； or e. SEQ ID NO: 102 of the variable heavy chain corresponds to HCDR1,
