Disclosed is an isolated antibody, or antigen-binding fragment thereof, that specifically binds human CD48 and blocks the interaction between human CD48 and a CD48 receptor, wherein the antibody or antigen binding fragment thereof comprises the heavy and light chains having the amino acid sequences of SEQ ID NO: 368 and 370 respectively or amino acid sequences having 90% identity to SEQ ID NO: 368 and 370. Further disclosed is an antibody comprising the complementarity determining region (CDR) domains HCDR1 (GFTFGGYA), HCDR2 (ISGSGGST), HCDR3 (AKYSNYDYFDP), LCDR1 (QSVSSSY), LCDR2 (GAS), and LCDR3 (QQYGSSPRT).
