ЭБ Ольга (US),ТАВАРЕС Дэниел (US),РУИ Линюнь (US),ПЭЙН Джиллиан (US),ГОЛДМАХЕР Виктор С. (US)
申请号：
RU2012135395/10
公开号：
RU2012135395A
申请日:
2011.02.24
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A humanized antibody or antigen binding fragment thereof specifically binding to the human folic acid receptor 1, comprising: (a) a heavy chain CDR1 comprising GYFMN (SEQ ID NO: 1)； Heavy chain CDR2 containing RIHPYDGDTFYNQXaaFXaaXaa (SEQ ID NO: 56)； and heavy chain CDR3 containing YDGSRAMDY (SEQ ID NO: 3)； and (b) a light chain CDR1 comprising KASQSVSFAGTSLMH (SEQ ID NO: 7)； Light chain CDR2 containing RASNLEA (SEQ ID NO: 8)； and CDR3 light chain containing QQSREYPYT (SEQ ID NO: 9)； where Xaa is selected from K, Q, H and R； Haav is selected from Q, I, N and R； and Haavybran from G, E, T, S, A, and V. 2. The humanized antibody or antigen binding fragment thereof according to claim 1, characterized in that the heavy chain CDR2 sequence contains RIHPYDGDTFYNQKFQG (SEQ ID NO: 2). 3. The humanized antibody or antigen binding fragment thereof according to claim 1 comprising a heavy chain variable domain of at least about 90%, about 95%, about 99%, about 100% identical to SEQ ID NO: 4, and the variable domain light chain, at least about 90%, about 95%, about 99%, about 100% identical to SEQ ID NO: 10 or SEQ ID NO: 11.4. The humanized antibody or its antigen-binding fragment encoded by plasmid DNA deposited in ATCC on April 7, 2010 under the accession numbers of ATCC PTA-10772, PTA-10773 or 10774.5. An antibody or antigen binding fragment thereof that specifically binds to the human folic acid receptor 1, comprising: (a) a heavy chain CDR1 containing SSYGMS (SEQ ID NO: 30)； Heavy chain CDR2 containing TISSGGSYTY (SEQ ID NO: 31)； and / or heavy chain CDR3 containing DGEGGLYAMDY (SEQ ID NO: 32)； and light chain CDR1 comprising KASDHINNWLA (SEQ ID NO: 27)； CDR2 light chain containing GATSLET (SEQ ID NO: 28)； and CDR3 light chain containing QQYWSTPFT (SEQ ID NO: 29)； (b) CDR1 is heavier�1. Гуманизированное антитело или его антиген-связывающий фрагмент, специфически связывающиеся с человеческим рецептором фолиевой кислоты 1, содержащее:(а) CDR1 тяжелой цепи, содержащую GYFMN
