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NOVI ANALOZI PIPERAZINA KAO ANTIVIRUSNA SREDSTVA ŠIROKOG SPEKTRA PROTIV VIRUSA GRIPE
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
CIANCI, CHRISTOPHER W.,GERRITZ, SAMUEL,LI, GUO,PEARCE, BRADLEY C.,PENDRI, ANNAPURNA,SHI, SHUHAO,ZHAI, WEIXU,ZHU, SHIRONG
申请号:
HRP20150228
公开号:
HRP20150228T1
申请日:
2015.02.26
申请国别(地区):
HR
年份:
2015
代理人:
摘要:
A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with —N, —O, or —S adjacent to the —Ar substituent or adjacent to the point of attachment for the —Ar substituent; Ar is aryl or heteroaryl; R is —CH3, —CH2F, or —CH═CH2; W is —NO2, —Cl, —Br, —CHO, —CH═CH2, or —CN; X is —Cl, —CH3, or —CN; Y is —CH or —N; and Z is C1-C6 alkyl, C3-C6 cycloalkyl, substituted aryl, substituted heteroaryl, OR1, or NHR1, wherein R1 is selected from the group of H, aryl, heteroaryl, C1-C6 alkyl and C3-C6 cycloalkyl. This compound is useful in compositions for the prevention and treatment of influenza virus.
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