KAHNERT, ANTJE,BERHÖRSTER, KERSTIN,HEISLER, IRING,KOPITZ, CHARLOTTE
申请号：
MYPI 2011005174
公开号：
MY158624A
申请日:
2010.04.16
申请国别(地区):
MY
年份:
2016
代理人:
摘要：
THE PRESENT INVENTION PROVIDES IMMUNOCONJUGATES COMPOSED OF ANTIBODIES, E.G., MONOCLONAL ANTIBODIES, OR ANTIBODY FRAGMENTS THAT BIND TO MESOTHELIN, THAT ARE CONJUGATED TO CYTOTOXIC AGENTS, E.G., MAYTANSINE, OR DERIVATIVES THEREOF, AND/OR CO- ADMINISTERED OR FORMULATED WITH ONE OR MORE ADDITIONAL ANTI-CANCER AGENTS. THE IMMUNOCONJUGATES OF THE INVENTION CAN BE USED IN THE METHODS OF THE INVENTION TO TREAT AND/OR DIAGNOSE AND/OR MONITOR CANCERS, E.G. SOLID TUMORS. THE IMMUNOCONJUGATES COMPRISE ANTIBODIES AND FUNCTIONAL FRAGMENTS CONTAINING SUCH ANTIGEN- BINDING REGIONS THAT ARE SPECIFIC FOR THE MEMBRANE-ANCHORED, 40 KDA MESOTHELIN POLYPEPTIDE, WHICH WHICH IS OVEREXPRESSED IN SEVERAL TUMORS, SUCH AS PANCREATIC AND OVARIAN TUMORS, MESOTHELIOMA AND LUNG CANCER CELLS.
