KAHNERT, ANTJE,BERHOERSTER, KERSTIN,HEISLER, IRING,KOPITZ, CHARLOTTE
申请号:
TW103146440
公开号:
TW201529084A
申请日:
2010.04.28
申请国别(地区):
TW
年份:
2015
代理人:
摘要:
The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. The immunoconjugates comprise antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.