BERHORSTER KERSTIN,HEISLER IRING,KOPITZ CHARLOTTE CHRISTINE,SCHUMACHER JOACHIM,KAHNERT ANTJE
申请号：
TN2011000547
公开号：
TN2011000547A1
申请日:
2011.10.27
申请国别(地区):
TN
年份:
2013
代理人:
摘要：
The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. The immunoconjugates comprise antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells.
