Paolo Lazzari;Gabriele Murineddu;Gerard Aime Pinna;Luca Pani;Giovanni Loriga;Stefania Ruiu
发明人:
Paolo Lazzari,Giovanni Loriga,Stefania Ruiu,Gabriele Murineddu,Luca Pani,Gerard Aime Pinna
申请号：
US12966371
公开号：
US08609659B2
申请日:
2010.12.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Diazapolycyclic compounds having affinity for the opioidergic receptors, preferably for the delta opioidergic receptors, with central and/or peripheral activity, having formula:A1-D1-T1 (I)wherein:A1 is a group of formula (II):wherein: R1 is phenyl wherein one of the ring hydrogen atoms is substituted with a group selected from C(O)R′, C(O)OR′, C(O)NHR′ or C(O)NR3R4, R′, R3 and R4, being as defined in the application； R2 is phenyl, optionally substitutedD1 is a diazapolycyclic groupT1 is a group selected from H, alkyl, alkenyl, alkynyl and from the following optionally substituted groups: cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl or heteroarylalkyl, and their hydrates and solvates and pharmaceutically acceptable salts.
