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Diazacyclic compounds having affinity for opioid receptors
专利权人:
发明人:
申请号:
EP10193857.9
公开号:
EP2338889B1
申请日:
2010.12.06
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
Diazapolycyclic compounds having affinity for the opioidergic receptors, preferably for the delta opioidergic receptors, with central and/or peripheral activity, having formula:         A1-D1-T1     (I)wherein:- A1 is a group of formula (II):wherein:R1 is phenyl wherein one of the ring hydrogen atoms is substituted with a group selected from C(O)R, C(O)OR, C(O)NHR or C(O)NR3R4, R, R3 and R4, being as defined in the application R2 is phenyl, optionally substituted- D1 is a diazapolycyclic group- T1 is a group selected from H, alkyl, alkenyl, alkynyl and from the following optionally substituted groups:cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl or heteroarylalkyl,and their hydrates and solvates and pharmaceutically acceptable salts.
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