Compound of Formula I, and pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof: ** Formula ** in which R 1 is selected from the group consisting of OH, C 1-4 alkyl, and halo； R2 is selected from the group consisting of H, OH, O-C1-4alkyl, and halo； each R3 are both H or, together, form = CH2； R4 is C1-4 alkyl； ---- represents a single link or a double link； each R5 can be the same or different, and is selected from the group consisting of hydrogen, halo and C1-4 alkyl, or each R5 can be taken together to form a C3-6 cycloalkyl ring； R6 is selected from the group consisting of C1-6 alkyl, C3-6 cycloalkyl, aryl and heteroaryl, wherein each of C1-6 alkyl, C3-6 cycloalkyl, aryl and heteroaryl is unsubstituted or it is substituted with 1-5 substituents independently selected from the group consisting of C1-4alkyl, O-C1-4alkyl, CF3, NO2 and halo； R7 is selected from the group consisting of H, C1-6 alkyl and C (O) R8； and R8 is selected from the group consisting of C1-6 alkyl, C3-6 cycloalkyl, aryl-C1-4 alkyl, aryl and heteroaryl, wherein each of C1-6 alkyl, C3- cycloalkyl 6, aryl and heteroaryl is unsubstituted or substituted with 1-5 substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkyl, CF 3, NO 2 and halo, with the proviso that when there is a double bond between C22 and C23, there is only one R5 group attached to C23, and R5 is selected from the group consisting of hydrogen, halo and C1-4 alkyl； said prodrugs being esters formed with a hydroxyl, thiol, amino or carboxy group available from the compounds of Formula I.Compuesto de Fórmula I, y sales, hidratos, solvatos y profármacos farmacéuticamente aceptables del mismo:**Fórmula** en la que R1 se selecciona de entre el grupo constituido por OH, O-alquilo de C1-4, y halo； R2 se selecciona de entre el grupo constituido por H, OH, O-alquilo de C1-4, y halo； cada R3 son ambos H o, juntos, forman =CH2； R4 es alquilo de C1-4； ---- representa un enlace sencillo o un
