Provided is an extract of Ginkgo biloba leaves as a crude drug, prepared by alcohol extraction of Ginkgo biloba leaves, comprising ≤4.0% of rutin, ≤0.4% of quercetin, 2.6-4.8% of bilobalide, 0.1-0.5% of ginkgolide J, ≤0.5% of residual ethanol, and ≤0.02% of biflavones, the biflavones comprising amentoflavone, bilobetin, and ginkgetin. The extract does not comprise genistin and ginkgolide M. Also provided is a method for preparing the extract of Ginkgo biloba leaves as a crude drug, comprising: extracting minced Ginkgo biloba leaves with an aqueous ethanol solution by heating under reflux, followed by filtration to obtain a filtrate； subjecting the filtrate to concentration followed by precipitation in water to obtain a supernatant, which is then centrifuged to obtain a centrifugate； loading the centrifugate to a macroporous resin column and conducting water washing and solvent elution to obtain a first eluate, then loading a low concentration solvent first eluate to a polyamide column and conducting water washing and ethanol elution to obtain a second eluate； combining the second eluate with a high concentration solvent first eluate and conducting concentration, followed by extraction, drying, milling, sieving, and blending. The resulting extract of Ginkgo biloba leaves as a crude drug can be prepared into various formulations containing the extract.L'invention concerne un extrait de feuilles de Ginkgo biloba destiné à former un médicament brut, préparé par extraction à l'alcool de feuilles de Ginkgo biloba, comprenant ≤ 4,0 % de rutine, ≤ 0,4 % de quercétine, 2,6 à 4,8 % de bilobalide, 0,1 à 0,5 % de ginkgolide J, ≤ 0,5 % d'éthanol résiduel et ≤ 0,02 % de biflavones, les biflavones comprenant de l'amentoflavone, de la bilobétine et de la ginkgétine. L'extrait ne comprend pas de génistine ni de ginkgolide M. L'invention concerne également un procédé de préparation de l'extrait de feuilles de Ginkgo biloba destiné à former un médicament brut, comprenant : l'extractio
