This invention relates to a litchi polyphenos extract capable of protecting liver and its manufacturing method. The litchi polyphenos extract is extracted from litchi fruits and includes procyanidin structured substance. Both the acute toxicity testing and in vitro testing, which have been conducted on the litchi polyphenos extract, have sufficiently proved that the litchi polyphenos extract has the functions of liver protection and alcoholic liver remedy.本發明有關於提供一種保護肝臟之荔枝多酚萃取物及其製造方法,該荔枝多酚萃取物係從荔枝果實中萃取出來,其包含一原花青素結構物。將該荔枝多酚萃取物進行急毒性試驗及體外試驗,都充分證明該荔枝多酚萃取物具有保護肝臟及修復酒精性肝臟之功能。