RNA transformation vectors derived from an uncapped single-component RNA virus

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专利权人:

LINDBO JOHN A.;POGUE GREGORY P.;TURPEN THOMAS H.

发明人:

LINDBO JOHN A.,POGUE GREGORY P.,TURPEN THOMAS H.

申请号：

US20010949317

公开号：

US2002164803(A1)

申请日:

2001.09.07

申请国别(地区):

美国

年份:

2002

代理人:

摘要：

This invention is directed to a plus strand RNA viral vector for transformation of a host organism with a foreign RNA, and expression of said foreign RNA. The foreign RNA is inserted into an infective RNA viral segment containing cis-acting viral replication elements, and allowed to infect the host organism. The RNA vector is modified to obtain infectivity by not incorporating a cap at the 5' end of the genome. The modified RNA is able to tolerate the exogenous RNA segment without disrupting the replication of the modified RNA, in the absence of a trans-acting viral replication element in a single component plant virus host cell.

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