FENICAL, William, H.,JENSEN, Paul, R.,MINCER, Tracy, J.,FELING, Robert, H., R.
申请号：
HK12109982.7
公开号：
HK1169120B
申请日:
2012.10.10
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.
