FENICAL, WILLIAM H.,JENSEN, PAUL R.,MINCER, TRACY J.,FELING, ROBERT H. R.
申请号：
PL11163737
公开号：
PL2441767T3
申请日:
2004.06.18
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hypoproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC 50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.
