William Fenical,Paul Jensen,Tracy Mincer,Robert H. R. Feling
申请号：
US12638860
公开号：
US08222289B2
申请日:
2009.12.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.
