Pharmaceutical compositions comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.本發明提供一種包含2-[6-(3-胺基-哌啶-1-基)-3-甲基-2,4-二側氧基-3,4-二氫-2H-嘧啶-1-基甲基]-4-氟-苯甲腈及其醫藥學上可接受之鹽的醫藥組合物以及包含該等醫藥組合物之套組及製品以及使用該等醫藥組合物之方法。