Pharmaceutical compositions comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1 (2H)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.本發明提供包含2-[[6-[(3R)-3-胺基-1-六氫吡啶基]-3,4-二氫-3-甲基-2,4-二氧代-1(2H)-嘧啶基]甲基]-苄腈及其醫藥上可接受之鹽的醫藥組合物,以及包含該等醫藥組合物之套組及製品,以及使用該等醫藥組合物之方法。