Pharmaceutical compositions comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.本發明提供包含2-[6-(3-胺基-六氫吡啶-1-基)-3-甲基-2,4-二氧代-3,4-二氫-2H-嘧啶-1-基甲基]-4-氟-苄腈及其醫藥上可接受之鹽的醫藥組合物以及包含該等醫藥組合物之套組及製品以及使用該等醫藥組合物之方法。